PDE-5 inhibitor, which stands for phosphodiesterase type 5, is a synthetic drug used to combat the effects of erectile dysfunction. If you are struggling with erectile dysfunction, PDE-5 inhibitors may help your sex life. PDE-5 inhibitors were the first synthetic effective oral treatment for erectile dysfunction and carry out their function by blocking the degradative action of phosphodiesterase type 5, a certain enzyme, on cyclic GMP, a cylic nucleotide derived from GTP. This action is carried out in the smooth muscle cells lining the blood vessels that supply blood to the corpus cavernosum of the penile region.
There are eight primary generic drugs that incorporate PDE-5, which are sold on the market: avanafil, lodenafil, mirodenafil, sildenafil, tadalafil, vardenafil, udenafil, and zaprinast. In October 2007, the U.S. Food and Drug administration announced that any drug containing a PDE-5 inhibitor must contain a label warning users of potential hearing loss. Other adverse drug reactions include headache, dizziness, flushing, dyspepsia and nasal congestion. These conditions appear to be dose related. Therefore, only take the prescribed amount – no more.
The three primary PDE-5 inhibitors are sildenafil, vardenafil, and tadalafil. You’ll likely recognize these drugs from their brand names: Viagra, Levitra, and Cialis. Most men who struggle with ED have taken at least one of these inhibitors in their lifetime. Although all three of these drugs use the same mechanism to prevent ED, they have differing pharmacological effects, which translates into unique clinical trials.
Sildenafil, which I’ll refer to as Viagra forthwith, shares a very similar molecular structure to vardenafil, or Levitra. However, tadalafil, or Cialis, has a much different chemical structure, although it still carries out the all-important function of blocking PDE-5.
Food, particularly fatty food, delays the absorption of both Viagra and Levitra, but has no effect on Cialis. Therefore, if you find yourself constantly eating, it may be best to purchase Cialis, instead of one of the other two. Viagra and Levitra have a half-life of only four hours, while Cialis has a half-life of seventeen hours. This is a critical statistic for the end user. If you know a specific time you’ll be having sex, say at 9 pm on a Friday night, then Viagra and Levitra are the best options. However, if you prefer spontaneous sexual relations, Cialis is the best option due to its long half-life. Half-life, by the way, is the length of time it takes for your body to process and metabolize half of a certain dose.
Men with certain conditions should refrain from using PDE-5 inhibitors without the expressed consent of a physician. These conditions are severe heart disease, severe heart failure, uncontrolled diabetes, high blood pressure, hypotension, recent history of stroke, and retinitis pigmentosa. If taken, doses are effective within 30 to 60 minutes, depending on how full your stomach is. PDE-5 inhibitors are not always effective with first-time users. It often takes multiple tries, so don’t be discouraged if there aren’t immediate results. Take back your sex life today, and purchase a PDE-5 inhibitor!
Safe, natural and effective: we often hear these words when it comes to health solutions. Veyromax is a proven system studied and researched by Japanese researchers, assuring that it can provide high quality results that you can truly see. The use of natural herbs and ingredients as well as proper proportions is designed to ensure maximum potency against male sexual dysfunctions. Veyromax is a top notch natural solution for those who are looking for alternatives to those expensive and often times, risky prescription drugs.
Veyromax has been created to provide maximum potency for numerous male performance problems and dysfunctions. Thanks to exhaustive scientific research, Veyromax is a perfect mix of well-proportioned ingredients such as Tribulus Terrestris, Muira Puama, Maca, Ginseng and Tongkat Ali, all with their very own verifiable medical benefits for human usage. These unique ingredients are also proven beneficial to a host of physical problems to boost energy while ensuring safety against any side effects.